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We are interested in understanding the cellular and molecular mechanisms underlying cancer cell plasticity in metastasis and therapy resistance. By using dynamic analyses of the tumour microenvironment and metastatic niche in human samples and preclinical models, in conjunction with single cell omics, imaging and computational analyses, we aim to achieve a systems-level understanding of the molecular circuits driving metastasis and therapy resistance.
Cancer cell plasticity
Cell-cell communication
Cell intrinsic factors
DC
TAM
NK
CD8 T
CD4 T
Endothelial
Fibroblast
dedifferentiation
EMT/MET
Transcription factors
Mutations
Epigenetic
modifications
TAM
CD8 T
CAFs
cytokines
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